PTH(1-34) Treatment Increases Bisphosphonate Turnover in Fracture Repair in Rats.
RatFractureClosed femurWistarMale25 micrograms/kg/day
Model: Closed femoral fracture repair model and a normal growth model, in animals dosed with labelled bisphosphonates (Alexa647-pamidronate and carbon-14 zoledronic acid)
PTH(1-34) significantly reduced bisphosphonate content in long bones and fracture callus, consistent with increased bisphosphonate remobilisation, but the reduction was not sufficient to alter callus bone volume.
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