Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism.
MouseChemical/toxinICRMalen = Four groups of eight mice; n=8 for biochemistry, n=5 to 6 f…Oral20 or 80 mg/kg30 minutes after carbon tetrachloride administration
Model: Acute liver injury induced by intraperitoneal carbon tetrachloride dissolved in olive oil, with sacrifice 24 hours later
Oral quercetin given after carbon tetrachloride lowered serum ALT and AST at 80 mg/kg, improved histology, reduced malondialdehyde and 4-hydroxynonenal, normalised glutathione and reversed the fall in antioxidant gene expression.
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.