The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
MouseChemical/toxinC57BL/6Malen = 2 to 5 mice per group per individual experiment, repeated m…Oral, in drinking water10 mg/kg/day (5 and 10 mg/kg/day compared; final concentrat…Pretreatment started 3 days before injury
Model: Acid-induced acute lung injury with 75 microlitres of hydrochloric acid buffered in 0.02 M citric acid instilled intratracheally, acetaminophen liver injury at 300 mg/kg intraperitoneally after overnight fast, and zymosan peritonitis with 100 micrograms intraperitoneally as a control stimulus
Febuxostat lowered serum, lung and liver uric acid and reduced neutrophilic inflammation after acid lung injury and acetaminophen liver injury, but did not reduce zymosan peritonitis, indicating it is not a general anti-inflammatory.
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