Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation.
MouseRadiationB6D2F1 recipients; C57BL/6 donorsFemaleOralStarted on day 14 after transplantation
Model: Lethal total body irradiation followed by allogeneic bone marrow and splenic T cell transplantation, inducing noninfectious lung injury and acute graft-versus-host disease
Preventive azithromycin improved survival and reduced noninfectious lung injury, with improved pulmonary function, reduced inflammatory infiltrates, less collagen deposition and lower lung cytokine and chemokine expression. Intestinal graft-versus-host disease improved at week 6 and liver disease a…
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