Acute focal brain damage alters mitochondrial dynamics and autophagy in axotomized neurons.
MouseTBIUnspecifiedC57BL/6 and GFP-LC3 transgenicIntraperitoneal2 mg/kg, dissolved in DMSO at 25 mg/ml
Model: Hemicerebellectomy causing remote degeneration of axotomized precerebellar neurons
Hemicerebellectomy depolarised mitochondria in axotomized precerebellar neurons with mitochondrial accumulation of PINK1, Parkin, p62 and Drp1, loss of Mfn1 and increased calcineurin activity. A single 2 mg/kg intraperitoneal dose of rapamycin increased GFP-LC3 puncta and LC3-II, reduced cytochrome…
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