Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats.
RatFractureUnspecifiedObese Zucker and lean ZuckerMaleIntraperitoneal and oral (drinking water)50 mg/kg intraperitoneally and 2 mM in drinking waterAfter trauma
Model: Orthopaedic trauma (soft tissue and bone injury) causing acute kidney injury
Obese Zucker rats developed acute kidney injury after trauma with reduced glomerular filtration rate, raised plasma creatinine, urine kidney injury molecule-1 and albumin excretion, increased NADPH oxidase activity and lipid peroxidation, and suppressed superoxide dismutase. Apocynin significantly…
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