Anti-inflammatory and protective properties of daphnetin in endotoxin-induced lung injury.
MouseEndotoxin/LPSC57BL/6
Model: Endotoxin (lipopolysaccharide) induced acute lung injury
Daphnetin conferred substantial protection from endotoxin-induced acute lung injury with reduced inflammatory mediator production, airway response and inflammatory cell infiltration, acting largely through induction of TNFAIP3 and suppression of NF-kappaB; the benefit was partially abrogated by TNF…
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