Excessive alpha-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Tocopherol transfer protein-deficient miceMaleDietaryDiet containing alpha-tocopherol at the equivalent human do…Mice maintained on the diet before stroke, giving supraphysiologic brain levels…
Model: Acute ischaemic stroke
Supraphysiologic brain alpha-tocopherol exacerbated ischaemic stroke-induced brain injury, with increased cortical S100B and RAGE at 48 hours, aggravated microglial activation and neuroinflammatory signalling, and increased markers of oxidative injury and neurodegeneration.
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