Role of Mitochondrial Calcium Uniporter in Early Brain Injury After Experimental Subarachnoid Hemorrhage.
RatHaemorrhage/shockUnspecifiedSprague-DawleyMale
Model: Experimental subarachnoid haemorrhage with assessment of early brain injury in the temporal cortex at 1, 2 and 3 days
Blockade of the mitochondrial calcium uniporter with ruthenium red prevented calcium accumulation, lowered oxidative stress, improved ATP production and reduced cytochrome c release, caspase-3 cleavage and apoptosis after subarachnoid haemorrhage, and spermine also lessened calcium accumulation.
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