Fluoxetine prevents oligodendrocyte cell death by inhibiting microglia activation after spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6 (from MeSH indexing, not stated in abstract)Male (from MeSH indexing, not stated in abstract)Intraperitoneal10 mg/kgAfter injury; exact start time not stated, outcomes assessed at 5 days after in…
Model: Contusion spinal cord injury at the T9 level using a Precision Systems and Instrumentation impactor device
Fluoxetine inhibited microglial activation and p38-MAPK signalling, reduced pro-NGF expression, caspase-3 activation and oligodendrocyte death, and limited myelin and axon loss at 5 days after spinal cord injury.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.