rhPDGF-BB promotes early healing in a rat rotator cuff repair model.
RatOtherSprague-DawleyMalen = 95 male rats randomised into five groups; per-group numbers…Local delivery on a collagen scaffold at the repair site30, 100 and 300 microg/mL rhPDGF-BB on the collagen scaffoldAt the time of acute supraspinatus tendon repair
Model: Acute detachment and repair of the supraspinatus tendon (rotator cuff repair model)
rhPDGF-BB produced a dose-dependent increase in cellular proliferation and angiogenesis at 5 days but did not improve fibrocartilage formation or collagen maturity at 28 days, and all scaffold-containing groups had lower load to failure and stiffness than repair-only controls.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.