Comparison of the Effects of Methotrexate and Methylprednisolone in Spinal Cord Injury in Rats.
RatSpinal cord injuryCompressionWistar albinon = 100 Wistar albino rats divided into 5 groupsIntraperitonealAfter clip compression
Model: Laminectomy followed by spinal cord injury induced with a temporary aneurysm clip compression
Neither methotrexate nor methylprednisolone reduced the histopathological damage grade at either stage, although low-dose methotrexate lowered lipid peroxidation in the sub-acute stage and was reported as more effective than methylprednisolone.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.