Melatonin treatment protects against acute spinal cord injury-induced disruption of blood spinal cord barrier in mice.
MouseSpinal cord injuryUnspecifiedC57BL/6 (from MeSH indexing, not stated in abstract)Male (from MeSH indexing, not stated in abstract)Intraperitoneal5, 10, 25, 50 and 100 mg/kg; 50 mg/kg most effectiveImmediately following spinal cord injury
Model: Acute spinal cord injury in mice (model details not stated in the abstract)
Melatonin at 50 mg/kg given immediately after spinal cord injury reduced blood spinal cord barrier permeability, limited microvessel loss and oedema, preserved tight junction proteins, endothelial cells and pericytes, and lowered apoptosis and MMP3, AQP4, HIF-1alpha, VEGF and VEGFR2 expression.
Extraction: extract · Supplied extraction confidence: 0.68. Machine-extracted fields require source verification.