Effect of erythropoietin on acoustically traumatized rat cochlea: an immunohistochemical study.
RatOtherWistar albinoMalen = 22 male rats: sham n = 7, erythropoietin n = 8, saline n = 7
Model: Acoustic overstimulation with white noise at 100 dB sound pressure level for 3 hours causing cochlear injury
Saline-treated noise-exposed rats showed significant threshold shifts for click and 6 kHz stimuli immediately after noise, whereas erythropoietin-treated rats did not. Erythropoietin also reduced the number of apoptotic cells in the cochlea.
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