The Effect of Control-released Basic Fibroblast Growth Factor in Wound Healing: Histological Analyses and Clinical Application.
MouseWoundC57BL/6JMalen = n = 4 wounds per group at each time point in mice; 8 patien…Topical application to the wound7 micrograms per cm2 impregnated in the gelatin sheet; comp…Applied immediately after wounding
Model: Bilateral 6 mm full-thickness excisional dorsal skin wounds by punch biopsy, splinted with an 8 mm inner diameter silicone stent to force healing by secondary intention
bFGF-impregnated gelatin sheet gave faster wound closure at day 7 (44.8 +/- 5.2 percent) than daily bFGF spray (37.3 +/- 3.7 percent), gelatin plus saline (26.8 +/- 5.5 percent) and saline alone (26.3 +/- 9.3 percent). It also gave greater mature collagen density at day 7 and higher CD31 vessel cou…
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