Changes in rat spinal cord gene expression after inflammatory hyperalgesia of the joint and manual therapy.
RatOtherSprague-Dawleyn = 3 rats per group across 4 groups (12 total)Manual application to the knee jointOne day after carrageenan-induced injury
Model: Acute inflammatory joint injury induced by carrageenan injection into the ankle, producing inflammatory hyperalgesia
Ankle injury alone changed spinal cord gene expression, with 755 of 38,875 expressed sequence tags differentially expressed in the injury versus no-injury comparison and over-representation of ion homeostasis, transmembrane and disulfide bond categories. Manual therapy produced no differentially ex…
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