THERAPY DOSSIER · th-d9b00a2f72c8

Manual therapy (joint mobilisation applied to the knee of the injured limb)

Procedure · Manual therapy / joint mobilisation procedure; not a ChEMBL entity

Evidence & regulatory context

Mechanism: Manual therapy / joint mobilisation procedure; not a ChEMBL entity
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04270253 ↗NAcompleted

End-range Mobilization Effecting Pain and Physical Function in Knee Osteoarthritis

Osteoarthritis Knee

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25288712 ↗2014No effect reported

Changes in rat spinal cord gene expression after inflammatory hyperalgesia of the joint and manual therapy.

RatOtherSprague-Dawleyn = 3 rats per group across 4 groups (12 total)Manual application to the knee jointOne day after carrageenan-induced injury

Model: Acute inflammatory joint injury induced by carrageenan injection into the ankle, producing inflammatory hyperalgesia

Ankle injury alone changed spinal cord gene expression, with 755 of 38,875 expressed sequence tags differentially expressed in the injury versus no-injury comparison and over-representation of ion homeostasis, transmembrane and disulfide bond categories. Manual therapy produced no differentially ex…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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