Gastroprotective effect of the traditional herbal medicine, Sipjeondaebo-tang water extract, against ethanol-induced gastric mucosal injury.
RatChemical/toxinSpecific-pathogen-free Sprague-DawleyMalen = 7 rats per group in 4 groups (28 total) for the injury stud…Oral gavage200 mg/kg body weight; acute toxicity assessed at a single…2 h before administration of absolute ethanol
Model: Acute gastric mucosal injury induced by intragastric absolute ethanol at 5 mL/kg after an 18 h fast
SDTW markedly reduced ethanol-induced gastric haemorrhage and hyperaemia, comparable to omeprazole. Malondialdehyde fell from 1.47 +/- 0.17 to 0.91 +/- 0.13 micromol/mg protein and glutathione rose from 32.30 +/- 1.09 to 48.97 +/- 6.02 micromol/mg protein versus ethanol alone. Catalase, glutathione…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.