THERAPY DOSSIER · th-3be81d06bc64

Sipjeondaebo-tang water extract (SDTW), a ten-herb traditional prescription

Nutraceutical · Ten-herb traditional Korean prescription (Juzentaihoto / Shi-Quan-Da-Bu-Tang); no ChEMBL entity queried as no defined chemical entity exists. Human trials exist but only in oncology-supportive care and cold-hypersensitivity indications, none in trauma.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Ten-herb traditional Korean prescription (Juzentaihoto / Shi-Quan-Da-Bu-Tang); no ChEMBL entity queried as no defined chemical entity exists. Human trials exist but only in oncology-supportive care and cold-hypersensitivity indications, none in trauma.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03374345 ↗PHASE2/PHASE3completed

Efficacy and Safety of Sipjeondaebo-tang on Korean Patients With Cold Hypersensitivity in the Hands and Feet

Cold Hypersensitivity

Enrolment: 60 · Results not recorded

NCT02858856 ↗NAunknown

Sipjeondaebo-tang for Alleviating Fatigue Among Patients With Breast Carcinoma Receiving Chemotherapy

Breast Carcinoma

Enrolment: 48 · Results not recorded

NCT02468141 ↗NAcompleted

Effect of Sipjeondaebo-tang for Cancer Related Anorexia: Randomized Double Blinded Placebo Controlled Pilot Study

Cancer-related Problem/Condition

Enrolment: 32 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25280763 ↗2014Reported benefit

Gastroprotective effect of the traditional herbal medicine, Sipjeondaebo-tang water extract, against ethanol-induced gastric mucosal injury.

RatChemical/toxinSpecific-pathogen-free Sprague-DawleyMalen = 7 rats per group in 4 groups (28 total) for the injury stud…Oral gavage200 mg/kg body weight; acute toxicity assessed at a single…2 h before administration of absolute ethanol

Model: Acute gastric mucosal injury induced by intragastric absolute ethanol at 5 mL/kg after an 18 h fast

SDTW markedly reduced ethanol-induced gastric haemorrhage and hyperaemia, comparable to omeprazole. Malondialdehyde fell from 1.47 +/- 0.17 to 0.91 +/- 0.13 micromol/mg protein and glutathione rose from 32.30 +/- 1.09 to 48.97 +/- 6.02 micromol/mg protein versus ethanol alone. Catalase, glutathione…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.

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