Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.
RatBurnScaldWistarMaleIntravenous1000 U/kg5 min prior to induction of injury
Model: Thermal scald-burn injury inducing multiorgan dysfunction and acute lung injury
rhEPO given 5 min before scald burn significantly reduced markers of multiorgan dysfunction (liver, kidney, lung and serum cytokines). In lung it reduced histological signs of tissue injury, bronchoalveolar lavage inflammatory/injury markers, neutrophil chemotaxis and infiltration, GSK-3beta activa…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.