Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
MouseTBIControlled cortical impactC57BL/6 (Harlan Sprague Dawley)Malen = Brain edema n=4-5 per group; mRNA-seq 3 groups of 6 mice (R…Oral, as the sole source of drinking waterWater supersaturated with molecular hydrogen at 1.6-1.8 ppm…Started 24 h before controlled cortical impact or sham surgery and continued un…
Model: Controlled cortical impact to the right parietotemporal cortex via 4 mm craniotomy, 3 mm flat tip at 5.82 m/s to a depth of 1.2 mm for 47 ms at 73 psi driving pressure; sham mice underwent the full procedure without impact
Molecular hydrogen water roughly halved controlled cortical impact induced brain edema at 24 h and reversed the Keep edema index, abolished AT8 and Alz50 pathological tau staining in cortex and hippocampus, reduced Iba1 microglial activation and GFAP staining, restored AQP-4 and MMP-2, partly suppr…
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