Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan.
RatChemical/toxinWistarMale
Model: Carbon tetrachloride (CCl4)-induced liver injury, a model of acute and chronic liver intoxication
Six differentiating metabolites were identified in plasma and urine of CCl4-injured rats, mapping to tryptophan, sphingolipid, steroid hormone, lysine, glycine/serine/threonine and pentose phosphate pathways. Er-Zhi-Wan showed a hepatoprotective pharmacological effect, apparently by regulating thes…
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