THERAPY DOSSIER · th-62712e7e7155

Er-Zhi-Wan (EZW), a traditional Chinese medicine formula containing Fructus Ligustri Lucidi and Herba Ecliptae

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04842825 ↗PHASE3unknown

Sequential Kidney-Tonifying and Blood-Regulating Herbs (Er Zhi Wan combined with Si Wu Tang) to Improve IVF-ET Success in Ovarian Reserve Dysfunction

Infertility, Female

Enrolment: 200 · Results not recorded

NCT04935073 ↗PHASE3unknown

Short-term TCM Herb Intervention in the Freeze-all IVF Cycle (Er Zhi Wan combined with Si Wu Tang)

Infertility, Female

Enrolment: 90 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25245419 ↗2014Reported benefit

Integrated plasma and urine metabolomics coupled with HPLC/QTOF-MS and chemometric analysis on potential biomarkers in liver injury and hepatoprotective effects of Er-Zhi-Wan.

RatChemical/toxinWistarMale

Model: Carbon tetrachloride (CCl4)-induced liver injury, a model of acute and chronic liver intoxication

Six differentiating metabolites were identified in plasma and urine of CCl4-injured rats, mapping to tryptophan, sphingolipid, steroid hormone, lysine, glycine/serine/threonine and pentose phosphate pathways. Er-Zhi-Wan showed a hepatoprotective pharmacological effect, apparently by regulating thes…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Loading the evidence…