Protection of pattern electroretinogram and retinal ganglion cells by oncostatin M after optic nerve injury.
MouseCrushPeripheral-nerve crushBALB/cn = 40 mice total in optic nerve crush experiments (12 for 4-se…Intravitreal injection via 33-gauge needle3 micrograms in 2 microlitres per eye (OSM or CNTF); contro…Immediately after optic nerve crush, within 1 minute
Model: Unilateral intraorbital optic nerve crush 1-2 mm behind the globe using extra-fine self-closing forceps, for 4 seconds or 1 second; contralateral eye untreated
Two weeks after 4-second crush, OSM-treated eyes retained 42.0, 47.2 and 48.1 per cent of normal retinal ganglion cell density at 0.5, 1.0 and 1.5 mm eccentricity versus 13.7, 14.1 and 14.6 per cent in PBS-treated eyes (two-way ANOVA, effect of treatment P<0.001). After the milder 1-second crush, p…
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