THERAPY DOSSIER · th-24608f71d08e

Human recombinant oncostatin M (OSM); ciliary neurotrophic factor (CNTF) as a separate comparator agent

Biologic · Recombinant human oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) are gp130-family cytokines; research biologics, no confident ChEMBL match

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Recombinant human oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) are gp130-family cytokines; research biologics, no confident ChEMBL match
Target: Not recorded
Injury models: Crush
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25243471 ↗2014Reported benefit

Protection of pattern electroretinogram and retinal ganglion cells by oncostatin M after optic nerve injury.

MouseCrushPeripheral-nerve crushBALB/cn = 40 mice total in optic nerve crush experiments (12 for 4-se…Intravitreal injection via 33-gauge needle3 micrograms in 2 microlitres per eye (OSM or CNTF); contro…Immediately after optic nerve crush, within 1 minute

Model: Unilateral intraorbital optic nerve crush 1-2 mm behind the globe using extra-fine self-closing forceps, for 4 seconds or 1 second; contralateral eye untreated

Two weeks after 4-second crush, OSM-treated eyes retained 42.0, 47.2 and 48.1 per cent of normal retinal ganglion cell density at 0.5, 1.0 and 1.5 mm eccentricity versus 13.7, 14.1 and 14.6 per cent in PBS-treated eyes (two-way ANOVA, effect of treatment P<0.001). After the milder 1-second crush, p…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

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