Effects of oleuropein and pinoresinol on microvascular damage induced by hypoperfusion and reperfusion in rat pial circulation.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalePretreatment before bilateral common carotid artery occlusion
Model: Transient bilateral common carotid artery occlusion causing cerebral hypoperfusion followed by reperfusion, with pial microcirculation visualised by fluorescence microscopy through a closed cranial window
Bilateral common carotid artery occlusion and reperfusion caused arteriolar diameter reduction, microvascular leakage, venular leukocyte adhesion and reduced capillary perfusion. Pretreatment with oleuropein or pinoresinol, at the higher dose given before occlusion, produced dilation in all arterio…
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