THERAPY DOSSIER · th-21e4dede4b75

Oleuropein and pinoresinol, natural polyphenols, given alone and together

Nutraceutical · No confident ChEMBL match; olive-derived polyphenol

Evidence & regulatory context

Mechanism: No confident ChEMBL match; olive-derived polyphenol
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00789425 ↗PHASE2completed

Standardized Olive Extract vs Placebo in Postmenopausal Women With Decreased Bone Mineral Density

Osteoporosis · Osteopenia

Enrolment: 64 · Results not recorded

NCT04520126 ↗NAunknown

Effect of Olivomed (Olive Extract incl. Oleuropein/Hydroxytyrosol) on Cardiovascular Function in Coronary Artery Disease

Coronary Artery Disease

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25243351 ↗2015Reported benefit

Effects of oleuropein and pinoresinol on microvascular damage induced by hypoperfusion and reperfusion in rat pial circulation.

RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalePretreatment before bilateral common carotid artery occlusion

Model: Transient bilateral common carotid artery occlusion causing cerebral hypoperfusion followed by reperfusion, with pial microcirculation visualised by fluorescence microscopy through a closed cranial window

Bilateral common carotid artery occlusion and reperfusion caused arteriolar diameter reduction, microvascular leakage, venular leukocyte adhesion and reduced capillary perfusion. Pretreatment with oleuropein or pinoresinol, at the higher dose given before occlusion, produced dilation in all arterio…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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