A study of the effect of sequential injection of 5-androstenediol on irradiation-induced myelosuppression in mice.
MouseRadiationC3H/HeNMaleSubcutaneous50 mg/kgPre-treatment 1 day before irradiation, or post-treatment starting 1 h after ir…
Model: Whole-body sublethal gamma-irradiation (5 Gy) inducing myelosuppression
5-androstenediol significantly ameliorated the fall in peripheral neutrophils and platelets, though not lymphocytes, reduced bone marrow hypocellularity and disruption, sped myeloid recovery, and attenuated the loss of spleen weight and splenic megakaryocyte and myeloid populations. A single inject…
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