Evidence & regulatory context
- Mechanism
- No ChEMBL mechanism-of-action table record. Endogenous adrenal steroid (5-androstene-3beta,17beta-diol), natural product flag true, max_phase -1 (clinical phase unknown in ChEMBL).
- Target
- Not recorded
- Injury models
- Radiation
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Preclinical/no trial
- ChEMBL max phase
- -1 / 4 (development scale, not regulatory approval)
- Synonyms
- Androstenediol; HE-2100; HE2100; Neumune; NSC-12163
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
MouseRadiationC3H/HeNMaleSubcutaneous50 mg/kgPre-treatment 1 day before irradiation, or post-treatment starting 1 h after ir…
Model: Whole-body sublethal gamma-irradiation (5 Gy) inducing myelosuppression
5-androstenediol significantly ameliorated the fall in peripheral neutrophils and platelets, though not lymphocytes, reduced bone marrow hypocellularity and disruption, sped myeloid recovery, and attenuated the loss of spleen weight and splenic megakaryocyte and myeloid populations. A single inject…
Extraction: extract · Supplied extraction confidence: 0.78. Machine-extracted fields require source verification.
MouseRadiationCD2F1 (antibody blocking and survival studies); C3H/HeN (phagocytosis, oxidative burst and PCR studies); C3H/FeJ (halo-comet assays)Malen = Neutralising antibody experiments repeated twice with n = 1…Subcutaneous injection30 mg/kg s.c. for gene expression experiments; 10, 30 and 1…24 h before irradiation (pre-treatment); neutralising antibodies to G-CSF or IL…
Model: Acute radiation syndrome after total body irradiation: 9.25 Gy gamma at 0.6 Gy/min (survival), 3 Gy gamma (innate immune cell function), 7.5 Gy gamma (gene expression), and 1, 3 or 5 Gy X-rays at 2 Gy/min (comet assays)
After 9.25 Gy TBI, 30-day survival was 100% with 5-AED plus isotype control antibody versus 44% with vehicle plus isotype control; neutralising anti-G-CSF abolished the benefit (31% survival) whereas anti-IL-6 did not (100% survival), showing G-CSF dependence. 5-AED increased phagocytosis in circul…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
