Ischemia preconditioning protects rat submandibular glands from ischemia/reperfusion injuries.
RatIschaemia-reperfusionOther / unspecifiedWistarMaleLocal vascular occlusion of the submandibular gland3 min ischaemia followed by 3 min reperfusion, repeated thr…Before the index ischaemia/reperfusion insult
Model: In-situ submandibular gland ischaemia/reperfusion without denervation (90 min ischaemia followed by 1, 12, 24 or 72 h reperfusion)
Ischaemia/reperfusion produced acute inflammation, reduced tight junction width, and increased myeloperoxidase activity, reactive oxygen species and apoptotic cell numbers with secretory dysfunction, most marked at 1 and 12 h post-reperfusion and largely normalising by 72 h. Ischaemic preconditioni…
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