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PRECLINICAL PUBLICATION · 2014

Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 25201116 ↗2014Reported benefit

Curcumin improves the recovery of motor function and reduces spinal cord edema in a rat acute spinal cord injury model by inhibiting the JAK/STAT signaling pathway.

RatSpinal cord injuryContusionSprague-DawleyMaleIntraperitoneal40 mg/kg30 minutes after injury

Model: Acute spinal cord injury induced by a falling weight

Curcumin moderately improved locomotor recovery and reduced haemorrhage, oedema and neutrophil infiltration, with reduced aquaporin-4 and GFAP expression and suppressed JAK/STAT activation.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.