Evaluation of the effect of tranilast on rats with spinal cord injury.
RatSpinal cord injuryContusionSprague-DawleyIntravenous or oral30 mg/kg per day intravenously or 200 mg/kg per day orally
Model: Spinal cord injury by impaction
Both intravenous and oral tranilast improved motor recovery, reduced acute inflammatory cell invasion and Iba1 expression, and confined glial and fibrotic scarring with lower chondroitin sulfate levels than control.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.