PRECLINICAL PUBLICATION · 2014

Caspase-9 mediates photoreceptor death after blunt ocular trauma.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Pen1-XBIR3 (penetratin 1 linked X-linked inhibitor of apoptosis BIR3 domain)

PMID 25190658 ↗2014Reported benefit

Caspase-9 mediates photoreceptor death after blunt ocular trauma.

RatOtherFemaleUnilateral intravitreal injectionAfter ballistic injury

Model: Ballistic blunt ocular trauma producing bilateral commotio retinae

Caspase-9 was activated in photoreceptors 5 hours after injury, and Pen1-XBIR3 inhibition reduced photoreceptor death and preserved electroretinographic function, giving structural and functional neuroprotection.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.