Evidence & regulatory context
- Mechanism
- Fusion peptide (penetratin-1 + XIAP BIR3 domain); no confident ChEMBL match, preclinical
- Target
- Not recorded
- Injury models
- Other
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatOtherFemaleUnilateral intravitreal injectionAfter ballistic injury
Model: Ballistic blunt ocular trauma producing bilateral commotio retinae
Caspase-9 was activated in photoreceptors 5 hours after injury, and Pen1-XBIR3 inhibition reduced photoreceptor death and preserved electroretinographic function, giving structural and functional neuroprotection.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
