Subacute intranasal administration of tissue plasminogen activator promotes neuroplasticity and improves functional recovery following traumatic brain injury in rats.
RatTBIControlled cortical impactWistarMalen = Group sizes of 3 per group reported for the pharmacokinetic…Intranasal600 micrograms per rat, delivered as ten 3 microlitre dropsInitiated 7 days after traumatic brain injury (subacute phase)
Model: Controlled cortical impact traumatic brain injury
Subacute intranasal tPA improved cognitive and sensorimotor recovery, lowered the cortical stimulation threshold, enhanced dentate gyrus neurogenesis and corticospinal axonal sprouting, and raised mature brain-derived neurotrophic factor levels.
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