Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.
RatOtherWistarn = 48 rats randomised into 4 groupsSystemic administration (route not stated)Atorvastatin 20 mg/kg; celecoxib 10 mg/kg; combination 20 m…After rotator cuff tear and repair
Model: Experimental rotator cuff (supraspinatus) tear with surgical suture repair
Atorvastatin increased maximal loading by about 30% and stiffness by about 20% versus saline, and by about 33% and 50% versus celecoxib. Celecoxib alone did not affect tendon healing. Effects were blocked by an EP4 selective antagonist.
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