Effect of topically applied sildenafil citrate on wound healing: experimental study.
RatWoundSprague-DawleyFemalen = 25 rats, 5 sacrificed at each of 5 time pointsTopical1% and 5% sildenafil citrate gel prepared with carbopol
Model: Four dorsal excisional skin defects healing by secondary intention
Sildenafil citrate gel reduced defect area from day 3, dose dependently after day 7, increased vascularity from day 3, and increased acute inflammation from day 5 with greater granulation amount and maturation and chronic inflammation from day 7.
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