Beneficial effects of platelet-derived growth factor on hemorrhagic shock in rats and the underlying mechanisms.
RatHaemorrhage/shockUnspecifiedWistarIntravenous1 to 15 micrograms/kg
Model: Acute haemorrhagic shock
Systemic PDGF-BB improved haemodynamics, perfusion of liver and kidney, vascular reactivity and survival after haemorrhagic shock. The effect depended on endothelial integrity and myoendothelial gap junctions and was abolished by connexin 43 antisense but not connexin 40 antisense.
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