PRECLINICAL PUBLICATION · 2014

Rapamycin plays a neuroprotective effect after spinal cord injury via anti-inflammatory effects.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Rapamycin (sirolimus)

PMID 25171343 ↗2014Reported benefit

Rapamycin plays a neuroprotective effect after spinal cord injury via anti-inflammatory effects.

RatSpinal cord injuryUnspecifiedWistarFemale

Rapamycin reduced activated microglia and neutrophils in the damage zone, lowered TNF-alpha and IL-1beta expression, reduced apoptotic cells and increased neuronal survival after spinal cord injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.