Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntraperitonealHericium erinaceus mycelium 50 and 300 mg/kg; erinacine A 1…90 minutes after the onset of ischaemia
Model: Global cerebral ischaemia and reperfusion by occlusion of the two common carotid arteries (stroke animal model)
Hericium erinaceus mycelium reduced total infarct volume by 22% at 50 mg/kg and 44% at 300 mg/kg relative to untreated stroke animals, and erinacine A dose dependently reduced infarct volume, inflammatory cytokines, nitrotyrosine, p38 MAPK phosphorylation and CHOP expression.
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