VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury.
MouseIschaemia-reperfusionHepaticC57BL/6 wild type and VEGFR1 tyrosine kinase knockout (VEGFR1 TK-/-), including bone marrow chimerasMaleSystemic administration to VEGFR1 TK-/- mice (route not stated)During hepatic ischaemia and reperfusion
Model: Hepatic warm ischaemia and reperfusion by occlusion of the blood supply to the median and left hepatic lobes
VEGFR1 tyrosine kinase knockout mice showed delayed liver repair, sustained sinusoidal damage and reduced pro-angiogenic factor expression. Treatment with epidermal growth factor attenuated hepatocellular and sinusoidal injury in these mice.
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