Regional traumatic limb hypothermia attenuates distant hepatic and renal injury following blast limb trauma in rats.
RatOtherSprague-DawleyMalen = 8 rats per groupRegional application to the injured limbRegional hypothermia applied for 30 minutes, 60 minutes or…Immediately after the onset of blast injury
Model: Blast limb trauma created with chartaceous electricity detonators under anaesthesia
All regional hypothermia durations attenuated distant renal injury, while 60 minutes and 6 hours attenuated hepatic injury. All durations reduced plasma TNF-alpha and interleukin-6, liver and kidney myeloperoxidase and kidney malondialdehyde and raised antioxidant capacity, with 60 minutes the most…
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