THERAPY DOSSIER · th-d7efd4ccee36

Regional traumatic limb hypothermia

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25159252 ↗2014Reported benefit

Regional traumatic limb hypothermia attenuates distant hepatic and renal injury following blast limb trauma in rats.

RatOtherSprague-DawleyMalen = 8 rats per groupRegional application to the injured limbRegional hypothermia applied for 30 minutes, 60 minutes or…Immediately after the onset of blast injury

Model: Blast limb trauma created with chartaceous electricity detonators under anaesthesia

All regional hypothermia durations attenuated distant renal injury, while 60 minutes and 6 hours attenuated hepatic injury. All durations reduced plasma TNF-alpha and interleukin-6, liver and kidney myeloperoxidase and kidney malondialdehyde and raised antioxidant capacity, with 60 minutes the most…

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Loading the evidence…