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PRECLINICAL PUBLICATION · 2014

The microRNA-146a/b attenuates acute small-for-size liver graft injury in rats.

Rat / Ischaemia-reperfusion

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 25156638 ↗2014Reported benefit

The microRNA-146a/b attenuates acute small-for-size liver graft injury in rats.

RatIschaemia-reperfusionHepaticSprague-DawleyMaleTail vein injectionAdministered in the small-for-size liver graft model (timing not stated)

Model: Small-for-size liver graft transplantation injury; in vitro NR8383 rat macrophages and rat liver Kupffer cells

miR-146a and miR-146b levels fell in small-for-size liver grafts, and administration of miR-146a and miR-146b mimics prevented graft injury through inactivation of IRAK1 and TRAF6.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.