THERAPY DOSSIER · th-d188ccf8a6df

miR-146a and miR-146b mimics

Other · RNA interference (miR-146a/b mimics); not a ChEMBL entity, preclinical

Evidence & regulatory context

Mechanism: RNA interference (miR-146a/b mimics); not a ChEMBL entity, preclinical
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25156638 ↗2014Reported benefit

The microRNA-146a/b attenuates acute small-for-size liver graft injury in rats.

RatIschaemia-reperfusionHepaticSprague-DawleyMaleTail vein injectionAdministered in the small-for-size liver graft model (timing not stated)

Model: Small-for-size liver graft transplantation injury; in vitro NR8383 rat macrophages and rat liver Kupffer cells

miR-146a and miR-146b levels fell in small-for-size liver grafts, and administration of miR-146a and miR-146b mimics prevented graft injury through inactivation of IRAK1 and TRAF6.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

Loading the evidence…