Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury.
MouseSpinal cord injuryContusionC57BL/6Female
Model: Contusion spinal cord injury
Interleukin-33 was upregulated with nuclear localisation predominantly in astrocytes after injury. Recombinant interleukin-33 treatment reduced tissue loss, demyelination and astrogliosis and markedly improved functional recovery, with persistent M2 microglia and macrophage activation and a periphe…
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