Preoperative dietary restriction reduces intimal hyperplasia and protects from ischemia-reperfusion injury.
Model: Bilateral renal ischaemia-reperfusion by microvascular clamping of the renal pedicle for 25 or 30 minutes; hepatic ischaemia-reperfusion by 30 minute clamping of the portal vein, hepatic artery and bile duct to the left and median lobes (70 per cent of liver ischaemic); carotid focal stenosis model of intimal hyperplasia created with a 9-0 nylon suture over a blunt 35 gauge needle, reducing vessel diameter by about 78 per cent
One week of preoperative protein and energy restriction reduced serum urea and creatinine and cortico-medullary tubular necrosis after renal ischaemia-reperfusion, and reduced ALT, AST and haemorrhagic necrosis at 3 and 24 hours after hepatic ischaemia-reperfusion. Three days of water-only fasting…
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