Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Ischaemia-reperfusion
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 1
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial
Perioperative Care · Intermittent Fasting · Carbohydrate Loading · Preoperative Fasting · Orthopedic Surgery · Insulin Resistance
Enrolment: 75 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseIschaemia-reperfusionHepaticC57BL/6J and B6D2F1 hybrid (C57BL/6 x DBA/2)Malen = Renal ischaemia-reperfusion functional markers n=5 per grou…Oral, dietaryProtein-free diet based on D12450BSpx providing 10 per cent…Preoperative: 1 week of protein-free diet, or 3 days of water-only fasting, imm…
Model: Bilateral renal ischaemia-reperfusion by microvascular clamping of the renal pedicle for 25 or 30 minutes; hepatic ischaemia-reperfusion by 30 minute clamping of the portal vein, hepatic artery and bile duct to the left and median lobes (70 per cent of liver ischaemic); carotid focal stenosis model of intimal hyperplasia created with a 9-0 nylon suture over a blunt 35 gauge needle, reducing vessel diameter by about 78 per cent
One week of preoperative protein and energy restriction reduced serum urea and creatinine and cortico-medullary tubular necrosis after renal ischaemia-reperfusion, and reduced ALT, AST and haemorrhagic necrosis at 3 and 24 hours after hepatic ischaemia-reperfusion. Three days of water-only fasting…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.