Potential protection of vitamin C against liver-lesioned mice.
MouseChemical/toxinMaleDescribed as vitamin C intake, supplementation and consumption; route not explicitly specifiedDose-dependent effects were reported but the specific dose…
Model: Carbon tetrachloride (CCl4)-induced acute liver injury
Vitamin C supplementation improved vital signs of CCl4-lesioned mice and produced a dose-dependent reduction of hepatomegaly. Serum ALT and AST were lowered and blood plasma lactic acid decreased. Hepatic SOD and GSH-PX activities increased while MDA content fell. Hepatotoxic injury was attenuated…
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