Hindlimb stretching alters locomotor function after spinal cord injury in the adult rat.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 19 young adult female rats in total: acute stretch group n…Manual external application to the hindlimbs with the animal held supine and wrapped in a towelApproximately 30 min per session, comprising 1 full minute…Acute stretch group began at post-injury day 4; a chronic stretch subgroup of c…
Model: Moderate contusive spinal cord injury (12.5 g-cm) delivered at the T10 spinal cord level with the NYU Impactor after a single level laminectomy at T9
Daily stretching significantly impaired locomotor recovery. Hindlimb function declined over the first 4 weeks with a saw-tooth pattern of transient loss after each session; BBB scores improved from weeks 5 to 10 but remained below controls, and deficits persisted after stretching ceased at 8 weeks.…
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